Publikationen von Dr. Silke C. Wenzel

Domen Pogorevc, Ying Tang, Michael Hoffmann, Gregor Zipf, Hubert S. Bernauer, Alexander Popoff, Heinrich Steinmetz, Silke C. Wenzel 
Biosynthesis and Heterologous Production of Argyrins. ACS Synthetic Biology (2019) 8 (5), pp. 1121–1133. 
DOI:10.1021/acssynbio.9b00023

Yan, F., Burgard, C., Popoff, A., Zaburannyi, N., Zipf, G., Maier, J., Bernauer, H.S., Wenzel, S.C., Müller, R. 
Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production. Chemical Science (2018) 9 (38), pp. 7510-7519. 
DOI: 10.1039/C8SC02046A

Sucipto, H., Pogorevc, D., Luxenburger, E., Wenzel, S.C., Müller, R. Heterologous production of myxobacterial α-pyrone antibiotics in Myxococcus xanthus. Metabolic Engineering (2017) 44, pp. 160-170. 
DOI: 10.1016/j.ymben.2017.10.004

Gemperlein, K., Hoffmann, M., Huo, L., Pilak, P., Petzke, L., Müller, R., Wenzel, S.C. Synthetic biology approaches to establish a heterologous production system for coronatines. Metabolic Engineering (2017) 44, pp. 213-222. 
DOI: 10.1016/j.ymben.2017.09.009

Burgard, C., Zaburannyi, N., Nadmid, S., Maier, J., Jenke-Kodama, H., Luxenburger, E., Bernauer, H.S., Wenzel, S.C. Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria. ACS Chem Biol. (2017) 12 (3), pp. 779-786. 
DOI: 10.1021/acschembio.6b00953

Wenzel, S.C., Müller, R. Host Organisms: Myxobacterium. In: Industrial Biotechnology: Microorganisms (2017) Part IV Chapter 12, pp. 453-485 
DOI: 10.1002/9783527807796.ch12

Lukat, P., Katsuyama, Y., Wenzel, S.C., Binz, T., König, C., Blankenfeldt, W., Brönstrup, M., Müller, R. Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity. Chemical Science (2017) 8 (11), pp. 7521-7527. 
DOI: 10.1039/c7sc02622f

Gemperlein, K., Zipf, G., Bernauer, H.S., Müller, R., Wenzel, S.C. Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase. Metab Eng. (2016) 33, pp. 98-108. 
DOI: 10.1016/j.ymben.2015.11.001

Wenzel, S.C., Hoffmann, H., Zhang, J., Debussche, L., Haag-Richter, S., Kurz, M., Nardi, F., Lukat, P., Kochems, I., Tietgen, H., Schummer, D., Nicolas, J.-P., Calvet, L., Czepczor, V., Vrignaud, P., Mühlenweg, A., Pelzer, S., Müller, R., Brönstrup, M. Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships. Angew Chem Int Ed Engl. (2015) 54 (51), pp. 15560-15564. 
DOI: 10.1002/anie.201508277

Sucipto, H., Sahner, J.H., Prusov, E., Wenzel, S.C., Hartmann, R.W., Koehnke, J., Müller, R. In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis. Chemical science (2015) 6 (8), pp. 5076-5085. 
DOI: 10.1039/c5sc01013f

Kling, A., Lukat, P., Almeida, D.V., Bauer, A., Fontaine, E., Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S.C., König, C., Ammerman, N.C., Barrio, M.B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P., Heinz, D.W., Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Tyagi, S., Fraisse, L., Grosset, J.H., Lagrange, S., Müller, R. Targeting DnaN for tuberculosis therapy using novel griselimycins. Science (2015) 348 (6239), pp. 1106-1112. 
DOI: 10.1126/science.aaa4690

Sahner, J.H., Sucipto, H., Wenzel, S.C., Groh, M., Hartmann, R.W., Müller, R. Advanced Mutasynthesis Studies on the Natural α-Pyrone Antibiotic Myxopyronin from Myxococcus fulvus. Chembiochem. (2015) 16 (6), pp. 946-953. 
DOI: 10.1002/cbic.201402666

Oßwald, C., Zaburannyi, N., Burgard, C., Hoffmann, T., Wenzel, S.C., Müller, R. A highly unusual polyketide synthase directs dawenol polyene biosynthesis in Stigmatella aurantiaca. J Biotechnol. (2014) 191, pp. 54-63. 
DOI: 10.1016/j.jbiotec.2014.07.447

Gemperlein, K., Rachid, S., Garcia, R.O., Wenzel, S.C., Müller, R. Polyunsaturated fatty acid biosynthesis in myxobacteria: Different PUFA synthases and their product diversity. Chemical science. (2014) 5 (5), pp. 1733-1741. 
DOI: 10.1039/c3sc53163e

Oßwald, C., Zipf, G., Schmidt, G., Maier, J., Bernauer, H.S., Müller, R., Wenzel, S.C. Modular construction of a functional artificial epothilone polyketide pathway. ACS Synth Biol. (2014) 3 (10), pp. 759-772. 
DOI: 10.1021/sb300080t

Sucipto, H., Wenzel, S.C., Müller, R. Exploring Chemical Diversity of α-Pyrone Antibiotics: Molecular Basis of Myxopyronin Biosynthesis. Chembiochem. (2013) 14 (13), pp. 1581-1589. 
DOI: 10.1002/cbic.201300289

Arnison, P.G., Bibb, M.J., Bierbaum, G., Bowers, A.A., Bugni, T.S., Bulaj, G., Camarero, J.A., Campopiano, D.J., Challis, G.L., Clardy, J., Cotter, P.D., Craik, D.J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P.C., Entian, K.-D., Fischbach, M.A., Garavelli, J.S., Göransson, U., Gruber, C.W., Haft, D.H., Hemscheidt, T.K., Hertweck, C., Hill, C., Horswill, A.R., Jaspars, M., Kelly, W.L., Klinman, J.P., Kuipers, O.P., Link, A.J., Liu, W., Marahiel, M.A., Mitchell, D.A., Moll, G.N., Moore, B.S., Müller, R., Nair, S.K., Nes, I.F., Norris, G.E., Olivera, B.M., Onaka, H., Patchett, M.L., Piel, J., Reaney, M.J.T., Rebuffat, S., Ross, R.P., Sahl, H.-G., Schmidt, E.W., Selsted, M.E., Severinov, K., Shen, B., Sivonen, K., Smith, L., Stein, T., Süssmuth, R.D., Tagg, J.R., Tang, G.-L., Truman, A.W., Vederas, J.C., Walsh, C.T., Walton, J.D., Wenzel, S.C., Willey, J.M., Van Der Donk, W.A. Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature. Nat Prod Rep. (2013) 30 (1), pp. 108-160. 
DOI: 10.1039/c2np20085f

Wenzel S.C., Müller R. Antibiotika (Buchkapitel), In: Industrielle Mikrobiologie. (2013) 8, pp.149-178. 
DOI 10.1007/978-3-8274-3040-3_8

Huo, L., Rachid, S., Stadler, M., Wenzel, S.C., Müller, R. Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis. Chem Biol. (2012) 19 (10), pp. 1278-1287. 
DOI: 10.1016/j.chembiol.2012.08.013

Wenzel, S.C., Müller, R. Naturstoffforschung: Naturstoffbiotechnologie des myxobakteriums Chondromyces crocatus. BioSpektrum (2011) 17 (5), pp. 580-582. 
DOI: 10.1007/s12268-011-0091-6

Wenzel, S.C., Müller, R. Myxobacteria - unique microbial secondary metabolite factories. In: Comprehensive Natural Products II: Chemistry and Biology. (2010) 2, pp. 189-222. 
ISBN: 9780080453811

Wenzel, S.C., Müller, R. The impact of genomics on the exploitation of the myxobacterial secondary metabolome. Nat Prod Rep. (2009) 26 (11), pp. 1385-1407. 
DOI: 10.1039/b817073h

Wenzel, S.C., Müller, R. Myxobacteria - 'microbial factories' for the production of bioactive secondary metabolites. Mol Biosyst. (2009) 5 (6), pp. 567-574. 
DOI: 10.1039/b901287g

Wenzel, S.C., Müller, R. The biosynthetic potential of myxobacteria and their impact in drug discovery. Curr Opin Drug Discov Devel. (2009) 12 (2), pp. 220-230. 
Pubmed: 19333867

Menche, D., Arikan, F., Perlova, O., Horstmann, N., Ahlbrecht, W., Wenzel, S.C., Jansen, R., Irschik, H., Müller, R. Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum. J Am Chem Soc. (2008) 130 (43), pp. 14234-14243. 
DOI: 10.1021/ja804194c

Binz, T.M., Wenzel, S.C., Schnell, H.-J., Bechthold, A., Müller, R. Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem.(2008) 9 (3), pp. 447-454. 
DOI: 10.1002/cbic.200700549

Wenzel, S.C., Bode, H.B., Kochems, I., Müller, R. A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin. Chembiochem. (2008) 9 (16), pp. 2711-2721. 
DOI: 10.1002/cbic.200800456

Fu, J., Wenzel, S.C., Perlova, O., Wang, J., Gross, F., Tang, Z., Yin, Y., Stewart, A.F., Müller, R., Zhang, Y. Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition. Nucleic Acids Res. (2008) 36 (17), pp. e113. 
DOI: 10.1093/nar/gkn499

Wenzel, S.C., Müller, R. Myxobacterial natural product assembly lines: Fascinating examples of curious biochemistry. Nat Prod Rep. (2007) 24 (6), pp. 1211-1224. 
DOI: 10.1039/b706416k

Frank, B., Wenzel, S.C., Bode, H.B., Scharfe, M., Blöcker, H., Müller, R. From Genetic Diversity to Metabolic Unity: Studies on the Biosynthesis of Aurafurones and Aurafuron-like Structures in Myxobacteria and Streptomycetes. J Mol Biol. (2007) 374 (1), pp. 24-38. 
DOI: 10.1016/j.jmb.2007.09.015

Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M.O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H.B., Bolten, C.J., Choudhuri, J.V., Doss, S., Elnakady, Y.A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A.C., Merai, M., Meyer, F., Mormann, S., Mũoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S.C., Suen, G., Treuner-Lange, A., Velicer, G.J., Vorhölter, F.-J., Weissman, K.J., Welch, R.D., Wenzel, S.C., Whitworth, D.E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A., Müller, R. Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol.(2007) 25 (11), pp. 1281-1289. 
DOI: 10.1038/nbt1354

Martens, T., Gram, L., Grossart, H.-P., Kessler, D., Müller, R., Simon, M., Wenzel, S.C., Brinkhoff, T. Bacteria of the Roseobacter clade show potential for secondary metabolite production. Microb Ecol. (2007) 54 (1), pp. 31-42. 
DOI: 10.1007/s00248-006-9165-2

Wenzel, S.C., Williamson, R.M., Grünanger, C., Xu, J., Gerth, K., Martinez, R.A., Moss, S.J., Carroll, B.J., Grond, S., Unkefer, C.J., Müller, R., Floss, H.G. On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. J Am Chem Soc. (2006) 128 (44), pp. 14325-14336. 
DOI: 10.1021/ja064408t

Stephan, S., Heinzle, E., Wenzel, S.C., Krug, D., Müller, R., Wittmann, C. Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide. Process Biochemistry (2006) 41 (10), pp. 2146-2152. 
DOI: 10.1016/j.procbio.2006.06.022

Wenzel, S.C., Meiser, P., Binz, T.M., Mahmud, T., Müller, R. Nonribosomal peptide biosynthesis: Point mutations and module skipping lead to chemical diversity. Angew Chem Int Ed Engl. (2006) 45 (14), pp. 2296-2301. 
DOI: 10.1002/anie.200503737

Wenzel, S.C., Müller, R. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol. (2005) 16 (6), pp. 594-606. 
DOI: 10.1016/j.copbio.2005.10.001

Wenzel, S.C., Müller, R. Heterologe Expression von komplexen myxobakteriellen Naturstoff-Biosynthesewegen in Pseudomonaden. BioSpektrum (2005) 11 (5), pp. 628-631. 
BioSpektrum.de

Dickschat, J.S., Bode, H.B., Wenzel, S.C., Müller, R., Schulz, S. Biosynthesis and identification of volatiles released by the myxobacterium Stigmatella aurantiaca. Chembiochem. (2005) 6 (11), pp. 2023-2033. 
DOI: 10.1002/cbic.200500174

Wenzel, S.C., Müller, R. Formation of novel secondary metabolites by bacterial multimodular assembly lines: Deviations from textbook biosynthetic logic (2005) 9 (5), pp. 447-458. Curr Opin Chem Biol. 
DOI: 10.1016/j.cbpa.2005.08.001

Mahmud, T., Wenzel, S.C., Wan, E., Wen, K.W., Bode, H.B., Gaitatzis, N., Müller, R. A biosynthetic pathway to isovaleryl-CoA in myxobacterial: The involvement of the mevalonate pathway (2005) 6 (2), pp. 322-330. Chembiochem. 
DOI: 10.1002/cbic.200400261

Wenzel, S.C., Kunze, B., Höfle, G., Silakowski, B., Scharfe, M., Blöcker, H., Müller, R. Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: Evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis. Chembiochem. (2005) 6 (2), pp. 375-385. 
DOI: 10.1002/cbic.200400282

Wenzel, S.C., Gross, F., Zhang, Y., Fu, J., Stewart, A.F., Müller, R. Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via Red/ET recombineering. Chem Biol. (2005) 12 (3), pp. 349-356. 
DOI: 10.1016/j.chembiol.2004.12.012

Wenzel, S.C., Bode, H.B. Novel polyene carboxylic acids from Streptomyces.  J Nat Prod. (2004) 67 (9), pp. 1631-1633. 
DOI: 10.1021/np049852t

Bode, H.B., Wenzel, S.C., Irschik, H., Höfle, G., Müller, R. Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosum. Angew Chem Int Ed Engl. (2004) 43 (32), pp. 4163-4167. 
DOI: 10.1002/anie.200454240

Dickschat, J.S., Wenzel, S.C., Bode, H.B., Müller, R., Schulz, S. Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. Chembiochem. (2004) 5 (6), pp. 778-787. 
DOI: 10.1002/cbic.200300813

Bode, H.B., Irschik, H., Wenzel, S.C., Reichenbach, H., Müller, R., Höfle, G. The leupyrrins: A structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum. J Nat Prod. (2003) 66 (9), pp. 1203-1206. 
Pubmed: 14510597

Bode, H.B., Zeggel, B., Silakowski, B., Wenzel, S.C., Reichenbach, H., Müller, R. Steroid biosynthesis in prokaryotes: Identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca. Mol Microbiol. (2003) 47 (2), pp. 471-481. 
DOI: 10.1046/j.1365-2958.2003.03309.x